Michele De Palma
Angiogenesi e targeting tumorale
(la pagina di Angiogenesi e targeting tumorale è momentaneamente disponibile solo in lingua inglese)
Our laboratory investigates the interactions between myeloid-lineage hematopoietic cells and the vascular system in tumors. By using targeted gene transfer vectors and conditional cell elimination strategies, we demonstrated that myeloid-lineage cells play an important role during tumor vascularization. In particular, we showed that tumor angiogenesis and growth are dependent on a distinct subset of circulating and tumor-infiltrating monocytes/macrophages. We are currently investigating how monocyte and macrophage heterogeneity in the tumor microenvironment influences angiogenesis and tumor responses to anti-angiogenic therapies. Furthermore, our studies will be applied to the screening and validation of candidate therapeutic targets and the development of novel cancer gene therapy strategies.
Our laboratory investigates the interactions between myeloid-lineage hematopoietic cells and the vascular system in tumors. By using targeted gene transfer vectors and conditional cell elimination strategies, we demonstrated that myeloid-lineage cells play an important role during tumor vascularization. In particular, we showed that tumor angiogenesis and growth are dependent on a distinct subset of circulating and tumor-infiltrating monocytes/macrophages. We are currently investigating how monocyte and macrophage heterogeneity in the tumor microenvironment influences angiogenesis and tumor responses to anti-angiogenic therapies. Furthermore, our studies will be applied to the screening and validation of candidate therapeutic targets and the development of novel cancer gene therapy strategies.
